“Why is Metformin prescribed for type 2 diabetes first (the side effects are HORRIBLE)?” Because it is the oldest, and SAFEST type 2 medication there is. It was first used in the U.S. in the 1950s - prior to that, there were NO medications for T2 (Type 2 diabetes mellitus). It actually does nothing to lower BG (Blood Glucose) levels - what it does is to inhibit the gluco-regulatory response that raises BG… which in T2’s is an issue due to the underlying biochemical failure of the cells to respond completely and efficiently to the action of insulin - which results in the release of the hormone glucagon which triggers a liver release of glucose into the bloodstream - raising the BG too high. By inhibiting that last step - metformin improves BG levels. It is the most effective medication there is for this - though in the last few years, researchers are starting to re-think the efficacy of using insulin for T2s sooner rather than later. As for side effects - the side of effects of
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